ImmunoCR
A repository of plant based immunomodulatory compounds
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Nutraceutical Profile

ImmunCR Id : ICR98
Chemical Name : Shogoal
Plant Source : Zingiber officinale Roscoe
Nutraceutical information : Edible, Ginger
Mode of administration : Oral
Immunomodulatory mechanism : Anti-cancer (upregulates ROS, activates caspase-3,-7, GADD 153 expression, regulates AKT/mtor pathway, PERK dephosphorylation, PARP degradation, downregulates MMP-9, G2/M cell cycle arrest); Nephroprotective (reduced BUN, creatinine, upregulates gshpx); Neuroprotective (upregulates HIF-1α, HO-1, regulates PI3K/Akt/mtor signaling pathway)
Description : Shogoal is extracted from ginger and forms through drying and thermal processing of gingerol. It is a phenolic compound having a pale-yellow and crystalline appearance, with [6]-shogoal as the most abundant analogue.

Chemical Structure Information

IUPAC Name (E)-1-(3-methoxy-4-trimethylsilyloxyphenyl)dec-4-en-3-one  
SMILES CCCCCC=CC(=O)CCC1=CC(=C(C=C1)O[Si](C)(C)C)OC
Formula C20H32O3Si
InchiKey NMBUJLNQCJYCNL-UHFFFAOYSA-N

Chemical Classification

Kingdom Organic compounds
Superclass Benzenoids
Class Phenol ethers
Subclass Anisoles

Physicochemical properties

LogP 6.666
Molecular weight 348.552
Hydrogen Bond Acceptor 3
Hydrogen Bond Donor 0
Polar surface area 35.16
No. of rotatable bonds 11
Number of Aromatic Rings 1
Number of rings 1

ADMET Properties

Absorption level Moderate
Solubility level Very Soluble
Blood Brain Barrier Very High
Plasma protein binding Binder
CYP2D6 inhibition Inhibitor

Other Biological Properties

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References

    1. https://doi.org/10.13040/IJPSR.0975-8232.12(10).5229-37
    2. https://doi: 10.1186/1476-4598-12-135
    3. https://agris.fao.org/agris-search/search.do?recordID=TR2020000231


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