ImmunCR Id : | ICR98 |
Chemical Name : | Shogoal |
Plant Source : | Zingiber officinale Roscoe |
Nutraceutical information : | Edible, Ginger |
Mode of administration : | Oral |
Immunomodulatory mechanism : | Anti-cancer (upregulates ROS, activates caspase-3,-7, GADD 153 expression, regulates AKT/mtor pathway, PERK dephosphorylation, PARP degradation, downregulates MMP-9, G2/M cell cycle arrest); Nephroprotective (reduced BUN, creatinine, upregulates gshpx); Neuroprotective (upregulates HIF-1α, HO-1, regulates PI3K/Akt/mtor signaling pathway) |
Description : | Shogoal is extracted from ginger and forms through drying and thermal processing of gingerol. It is a phenolic compound having a pale-yellow and crystalline appearance, with [6]-shogoal as the most abundant analogue. |
IUPAC Name | (E)-1-(3-methoxy-4-trimethylsilyloxyphenyl)dec-4-en-3-one |
SMILES | CCCCCC=CC(=O)CCC1=CC(=C(C=C1)O[Si](C)(C)C)OC |
Formula | C20H32O3Si |
InchiKey | NMBUJLNQCJYCNL-UHFFFAOYSA-N |
Kingdom | Organic compounds |
Superclass | Benzenoids |
Class | Phenol ethers |
Subclass | Anisoles |
LogP | 6.666 |
Molecular weight | 348.552 |
Hydrogen Bond Acceptor | 3 |
Hydrogen Bond Donor | 0 |
Polar surface area | 35.16 |
No. of rotatable bonds | 11 |
Number of Aromatic Rings | 1 |
Number of rings | 1 |
Absorption level | Moderate |
Solubility level | Very Soluble |
Blood Brain Barrier | Very High |
Plasma protein binding | Binder |
CYP2D6 inhibition | Inhibitor |