| ImmunCR Id : | ICR9 |
| Chemical Name : | Apigenin 7-O-β-d-galactoside |
| Plant Source : | Jatropha curcas |
| Nutraceutical information : | --- |
| Mode of administration : | Orally, Rectal Injection (in case of jaundice) |
| Immunomodulatory mechanism : | Suppressed the release of nitric oxide (NO), prostaglandin E2 (PGE2), and tumour necrosis factor-α (TNF-α) in LPS-stimulated RAW 264.7 macrophages, suppressed LPS-induced mrna expression of inducible nitric oxide synthase (inos), cyclooxygenase-2 (COX-2), and TNF-α. Decreased the translocation of c-Jun into the nucleus, and decreased activator protein-1 (AP-1)-mediated luciferase activity through the inhibition of both p38 mitogen-activated protein kinase (MAPK) and extracellular signal-regulated kinase (ERK) phosphorylation. AG may be used as a source of anti-inflammatory agents as well as a dietary complement for health promotion. Stimulation humoral and cell-mediated immune responses Protection against Newcastle disease |
| Description : | An apigenin-substituted glycosyloxyflavone with a -D-glucopyranosyl moiety at position 7 via glycosidic bond linkage, it also works as non-steroidal anti-inflammatory and antibacterial agent |
| IUPAC Name | --- |
| SMILES | Oc1ccc(cc1O)C=1Cc2c(OC3OC(CO)C(O)C(O)C3O)c(O)cc(O)c2C(=O)C=1 |
| Formula | C22H22O11 |
| InchiKey | OESWNXVFTDEXLD-UHFFFAOYSA-N |
| Kingdom | Organic compounds |
| Superclass | Benzenoids |
| Class | Naphthalenes |
| Subclass | Phenylnaphthalenes |
| LogP | 0.666 |
| Molecular weight | 462.403 |
| Hydrogen Bond Acceptor | 11 |
| Hydrogen Bond Donor | 8 |
| Polar surface area | --- |
| No. of rotatable bonds | 4 |
| Number of Aromatic Rings | 2 |
| Number of rings | 4 |
| Absorption level | --- |
| Solubility level | --- |
| Blood Brain Barrier | --- |
| Plasma protein binding | Non-Binder |
| CYP2D6 inhibition | Non-Inhibitor |
