| ImmunCR Id : | ICR8 |
| Chemical Name : | P-coumaric acid |
| Plant Source : | Plantago major |
| Nutraceutical information : | Edible, High fractions in barley, wheat, oat and corn |
| Mode of administration : | --- |
| Immunomodulatory mechanism : | P-Coumaric acid inhibited the catalytic activity of tyrosinase in vitro, especially toward human tyrosinase, inhibited tyrosinase gene expression stimulated by α-MSH. Prostaglandin reductase 1 (HUMANS), Histidine ammonia-lyase (Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)), Photoactive yellow protein ( Halorhodospira halophila), |
| Description : | It is an organic compound and one of the three isomers of hydroxycinnamic acid. It is a white solid that is extensively soluble in ethanol and diethyl ether but very moderately soluble in water. |
| IUPAC Name | (E)-3-(4-hydroxyphenyl)prop-2-enoic acid |
| SMILES | C1=CC(=CC=C1/C=C/C(=O)O)O |
| Formula | C9H8O3 |
| InchiKey | NGSWKAQJJWESNS-ZZXKWVIFSA-N |
| Kingdom | Organic compounds |
| Superclass | Phenylpropanoids and polyketides |
| Class | Cinnamic acids and derivatives |
| Subclass | Hydroxycinnamic acids and derivatives |
| LogP | 1.685 |
| Molecular weight | 164.158 |
| Hydrogen Bond Acceptor | 3 |
| Hydrogen Bond Donor | 2 |
| Polar surface area | 58.931 |
| No. of rotatable bonds | 2 |
| Number of Aromatic Rings | 1 |
| Number of rings | 1 |
| Absorption level | Good |
| Solubility level | Very Soluble |
| Blood Brain Barrier | Low |
| Plasma protein binding | Non-Binder |
| CYP2D6 inhibition | Non-Inhibitor |
