| Immunomodulatory mechanism :
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Neuroprotective (activates ERK signaling pathway, reduces acetylcholinesterase (ache) levels, increased levels of glutathione peroxidase, manganese-superoxide dimutase, prevents camkii, MAP2, glur1 protein level reduction, prevents dopaminergic neuron damage against MPP+ toxicity); Antioxidant (inhibits ROS, lipid peroxidation, elevates GSH levels, downregulates SOD2, CYP51A1 genes); Apoptosis (downregulates BCL2 gene expression); interacts with ERK, CREB, P13K/AKT signaling pathways; Anti-cancer (arrest S, G2/M phase, downregulates Wnt pathway, CD44v6 marker, inhibits TGF-β, ZEB, Slug, Snail, oncogene factors STAT3, NF-κb, P13K, AKT, upregulates onco-suppressor factors microrna-7, 200b); Cardioprotective (activates ABCG2, AKR1B1)
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| Description : |
Nobiletin or 3′,4′,5,6,7,8-hexamethoxyflavone is a bioactive polymethoxylated flavones found in citrus fruits, with high absorption rate across cytoplasmic membrane credited to the lipophilic nature and its structure.
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