Immunomodulatory Function of Nutritionals and Nutraceuticals for Health and Wellness

Nutraceutical Profile


ImmunCR Id :	ICR46
Chemical Name :	Β-Carotene
Plant Source :	Actinidia deliciosa
Nutraceutical information :	Edible, carrot, pumpkin, spinach, tomatoe, watermelon and raspberries, cow milk
Mode of administration :	Oral


Immunomodulatory mechanism :	Obesity (production of interleukin (IL)-1β, IL-6, and tumor necrosis factor-alpha (TNF-α), modulating the physiology of adipocytes by producing β-apo-14′-carotenal, regulate lipogenesis through suppression of the peroxisome-proliferator-activated receptor (PPAR)-y); Type 2 Diabetes Mellitus (insulin resistance induced by DEHP (di-2-ethylhexyl phthalate)); Anti-inflammatory ( inhibits NF-κb and reduced IL-1β, IL-18, attenuated TNF-α); Antioxidant (ROS scavenging); secretion of immunomodulatory lipid molecules like leukotrienes and prostaglandins; Supports accumulation of platelets that is responsible for reconstruction of blood vessels,
Description :	Β-Carotene a polyene compound belonging to the unoxidzed group of carotenoids with eight isoprene units and two β-ionone-ring at either ends. It is a secondary metabolite originating from acyclic structure and conjugated double bond along the long chain revealing its bright red-orange color. It is used as an additive in pharmaceutical industry for coloring the tablets and also for medicinal purpose due to its high bioactivity.

Immunomodulatory mechanism :

Obesity (production of interleukin (IL)-1β, IL-6, and tumor necrosis factor-alpha (TNF-α), modulating the physiology of adipocytes by producing β-apo-14′-carotenal, regulate lipogenesis through suppression of the peroxisome-proliferator-activated receptor (PPAR)-y); Type 2 Diabetes Mellitus (insulin resistance induced by DEHP (di-2-ethylhexyl phthalate)); Anti-inflammatory ( inhibits NF-κb and reduced IL-1β, IL-18, attenuated TNF-α); Antioxidant (ROS scavenging); secretion of immunomodulatory lipid molecules like leukotrienes and prostaglandins; Supports accumulation of platelets that is responsible for reconstruction of blood vessels,

Description :

Β-Carotene a polyene compound belonging to the unoxidzed group of carotenoids with eight isoprene units and two β-ionone-ring at either ends. It is a secondary metabolite originating from acyclic structure and conjugated double bond along the long chain revealing its bright red-orange color. It is used as an additive in pharmaceutical industry for coloring the tablets and also for medicinal purpose due to its high bioactivity.

Chemical Structure Information


IUPAC Name	1,3,3-trimethyl-2-[(1E,3E,5E,7E,9E,11E,13E,15E,17E)-3,7,12,16-tetramethyl-18-(2,6,6-trimethylcyclohexen-1-yl)octadeca-1,3,5,7,9,11,13,15,17-nonaenyl]cyclohexene
SMILES	CC1=C(C(CCC1)(C)C)C=CC(=CC=CC(=CC=CC=C(C)C=CC=C(C)C=CC2=C(CCCC2(C)C)C)C)C
Formula	C40H56
InchiKey	OENHQHLEOONYIE-UHFFFAOYSA-N

Chemical Classification


Kingdom	Organic compounds
Superclass	Lipids and lipid-like molecules
Class	Prenol lipids
Subclass	Tetraterpenoids

Physicochemical properties


LogP	11.998
Molecular weight	536.873
Hydrogen Bond Acceptor	0
Hydrogen Bond Donor	0
Polar surface area	0
No. of rotatable bonds	10
Number of Aromatic Rings	0
Number of rings	2

ADMET Properties


Absorption level	Very low
Solubility level	Very Soluble
Blood Brain Barrier	Undefined
Plasma protein binding	Binder
CYP2D6 inhibition	Inhibitor

Other Biological Properties