| ImmunCR Id : | ICR42 |
| Chemical Name : | Malvidin-3-galactoside |
| Plant Source : | Pericarpium |
| Nutraceutical information : | Edible, Richest source is Blueberry |
| Mode of administration : | --- |
| Immunomodulatory mechanism : | M3G suppressed proliferation, polarization, migration, and invasion activities of hepg2 cells by regulating the protein expression of cyclin D1, cyclin B, cyclin E, caspase-3, cleaved caspase-3, Bax, p-JNK, and p-p38, activating phosphatase and tensin homologue deleted on chromosome 10 (PTEN), accompanied by a decrease in the p-AKT level, and lowering the protein expression levels of MMP-2 and MMP-9. M3G promoted the apoptosis of liver tumor cells; immunohistochemistry (cleaved caspase-3, Ki-67, PTEN, and p-AKT); lowered the expression levels of cyclins D1 and B, suppressing the progression from G1 to S phase and from G2 to M phase; decreased expression of cyclin E in a dose-dependent manner, reduced HCC (heptacellular carcinoma) progression; increased the cleaved caspase-3 expression and decreased the Ki-67 expression in a concentration-dependent manner; Anti-inflammatory (inhibit tumor necrosis factor-alpha (TNF-α) induced increases of monocyte chemotactic protein-1 (MCP-1), intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1) production both in the protein and mrna levels in a concentration-dependent manner). |
| Description : | M3G is a member of Anthacyanin family |
| IUPAC Name | (2S,3R,4S,5R,6R)-2-[5,7-dihydroxy-2-(4-hydroxy-3,5-dimethoxyphenyl)chromenylium-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol |
| SMILES | COC1=CC(=CC(=C1O)OC)C2=[O+]C3=CC(=CC(=C3C=C2O[C@H]4[C@@H]([C@H]([C@H]([C@H](O4)CO)O)O)O)O)O |
| Formula | C23H25O12+ |
| InchiKey | PXUQTDZNOHRWLI-XSEKTIEYSA-O |
| Kingdom | Organic compounds |
| Superclass | Phenylpropanoids and polyketides |
| Class | Flavonoids |
| Subclass | Flavonoid glycosides |
| LogP | 1.317 |
| Molecular weight | 493.437 |
| Hydrogen Bond Acceptor | 11 |
| Hydrogen Bond Donor | 7 |
| Polar surface area | 193.983 |
| No. of rotatable bonds | 6 |
| Number of Aromatic Rings | 3 |
| Number of rings | 4 |
| Absorption level | Very low |
| Solubility level | Very Soluble |
| Blood Brain Barrier | Undefined |
| Plasma protein binding | Non-Binder |
| CYP2D6 inhibition | Non-Inhibitor |
