| ImmunCR Id : | ICR37 |
| Chemical Name : | Vitamin B6 |
| Plant Source : | Musa |
| Nutraceutical information : | Edible, found in various foods, including cereals, fish, liver and other organ meats, potatoes and starchy vegetables, legumes, nuts, bananas, avocados, non-citrus fruits, egg yolk, whole grains. |
| Mode of administration : | Oral, tablets |
| Immunomodulatory mechanism : | Metabolism of sphingosine phosphate(transformation of sphingosine-1-phosphate (S1P)), tryptophan catabolism(PLP is a cofactor of enzymes in the kynurenine pathway), action of the transcription factor NF-κb; reducing inflammation in the body by influencing the activity of inflammasomes and specifically its component, the NLRP3 sensory protein; blood pressure regulation (influence on the renin-angiotensin system) and blood clotting, ensuring endothelial integrity and platelet aggregation; regulation of the enzyme serine hydroxymethyltransferase 2 (SHMT2), which is involved in the metabolism of folate; Diabetes(type 2); B6 treatment increases cardiac levels of imidazole dipeptides (e.g., carnosine, anserine, and homocarnosine), histamine, and γ-aminobutyric acid (GABA) and suppresses P2X7 receptor-mediated NLRP3 infammasome |
| Description : | A water soluble vitamin acting as a coenzyme in 140 enzymes by converting to pyridoxal 5-phosphate, also known as pyridoxine. |
| IUPAC Name | 4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol |
| SMILES | CC1=NC=C(C(=C1O)CO)CO |
| Formula | C8H11NO3 |
| InchiKey | LXNHXLLTXMVWPM-UHFFFAOYSA-N |
| Kingdom | Organic compounds |
| Superclass | Organoheterocyclic compounds |
| Class | Pyridines and derivatives |
| Subclass | Pyridoxines |
| LogP | -0.49 |
| Molecular weight | 169.178 |
| Hydrogen Bond Acceptor | 4 |
| Hydrogen Bond Donor | 3 |
| Polar surface area | 73.707 |
| No. of rotatable bonds | 2 |
| Number of Aromatic Rings | 1 |
| Number of rings | 1 |
| Absorption level | Good |
| Solubility level | Very Soluble |
| Blood Brain Barrier | Low |
| Plasma protein binding | Non-Binder |
| CYP2D6 inhibition | Non-Inhibitor |
