| ImmunCR Id : | ICR32 |
| Chemical Name : | Ellagic acid |
| Plant Source : | Punica granatum |
| Nutraceutical information : | Edible, high content in pomegranate |
| Mode of administration : | Oral |
| Immunomodulatory mechanism : | Studied for treatment of Follicular Lymphoma (phase 2 trial), protection from brain injury of intrauterine growth restricted babies (phase 1 and 2 trial), improvement of cardiovascular function in adolescents who are obese (phase 2 trial), and topical treatment of solar lentigines; antioxidant and anti-proliferative effects. Inhibits the targets: Carbonic Anhydrase 1-5A, 5B(mitochondrial)-9, 12, 14, camp-dependent protein kinase catalytic subunit alpha, Protein kinase C alpha/beta, Tyrosine protein kinase SYK, Squalene monooxygenase |
| Description : | It is a polyphenol largely occuring as ellagitannins in dicotyledon plants, acting as an antioxidant. It is the dilactone of hexahydroxydiphenic acid. |
| IUPAC Name | 6,7,13,14-tetrahydroxy-2,9-dioxatetracyclo[6.6.2.04,16.011,15]hexadeca-1(15),4,6,8(16),11,13-hexaene-3,10-dione |
| SMILES | C1=C2C3=C(C(=C1O)O)OC(=O)C4=CC(=C(C(=C43)OC2=O)O)O |
| Formula | C14H6O8 |
| InchiKey | AFSDNFLWKVMVRB-UHFFFAOYSA-N |
| Kingdom | Organic compounds |
| Superclass | Phenylpropanoids and polyketides |
| Class | Tannins |
| Subclass | Hydrolyzable tannins |
| LogP | 1.584 |
| Molecular weight | 302.193 |
| Hydrogen Bond Acceptor | 8 |
| Hydrogen Bond Donor | 4 |
| Polar surface area | 135.723 |
| No. of rotatable bonds | 0 |
| Number of Aromatic Rings | 2 |
| Number of rings | 4 |
| Absorption level | Moderate |
| Solubility level | Very Soluble |
| Blood Brain Barrier | Undefined |
| Plasma protein binding | Binder |
| CYP2D6 inhibition | Non-Inhibitor |
