| ImmunCR Id : | ICR26 |
| Chemical Name : | Acetyl-11-keto-β-boswellic acid |
| Plant Source : | Boswellia serrata |
| Nutraceutical information : | --- |
| Mode of administration : | --- |
| Immunomodulatory mechanism : | It reduces leukocyte–endothelial cell interactions and tissue injury by blocking 5-LO action in a rat model of ileitis induced by indomethacin. It conferred protection in DSS colitis by attenuating disease activity index and recruitment of leucocytes and platelets, prevented P-selectin up-regulation, and protected colonic mucosa. It also prevents colonic fibrosis in TNBS colitis via inhibition of TGF-β1/Smad3 pathway, and stimulates repair of PNI via activation of the ERK signaling pathway. |
| Description : | AKBA is extracted from a native plant of India and Pakistan Boswellia serrata, it has a white powdery appearance with anti-inflammatory properties. |
| IUPAC Name | --- |
| SMILES | CC1CCC2(CCC3(C(=CC(=O)C4C3(CCC5C4(CCC(C5(C)C(=O)O)OC(=O)C)C)C)C2C1C)C)C |
| Formula | C32H48O5 |
| InchiKey | HMMGKOVEOFBCAU-UHFFFAOYSA-N |
| Kingdom | Organic compounds |
| Superclass | Lipids and lipid-like molecules |
| Class | Prenol lipids |
| Subclass | Triterpenoids |
| LogP | 6.081 |
| Molecular weight | 512.721 |
| Hydrogen Bond Acceptor | 5 |
| Hydrogen Bond Donor | 1 |
| Polar surface area | 81.648 |
| No. of rotatable bonds | 3 |
| Number of Aromatic Rings | 0 |
| Number of rings | 5 |
| Absorption level | low |
| Solubility level | Very Soluble |
| Blood Brain Barrier | Undefined |
| Plasma protein binding | Binder |
| CYP2D6 inhibition | Non-Inhibitor |
