ImmunoCR
A repository of plant based immunomodulatory compounds
ImmunoCR
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Nutraceutical Profile

ImmunCR Id : ICR23
Chemical Name : Cannabichromene
Plant Source : Cannabis Sativa
Nutraceutical information : ---
Mode of administration : ---
Immunomodulatory mechanism : Activates the transient receptor potential ankyrin-type1 and inhibits endocannabinoid inactivation, providing its role in inflammatory pathway. Beneficial effects in experimental colitis by decreasing NO production and ameliorates DNBS-induced colitic inflammation, by improving histology, immunohistochemistry, and myeloperoxidase activity
Description : It is a minor cannabinoid found in cannabis plant with the ability to stimulate brain and nerves.

Chemical Structure Information

IUPAC Name 2-methyl-2-(4-methylpent-3-enyl)-7-pentylchromen-5-ol  
SMILES CCCCCC1=CC(=C2C=CC(OC2=C1)(C)CCC=C(C)C)O
Formula C21H30O2
InchiKey UVOLYTDXHDXWJU-UHFFFAOYSA-N

Chemical Classification

Kingdom Organic compounds
Superclass Organoheterocyclic compounds
Class Benzopyrans
Subclass 1-benzopyrans

Physicochemical properties

LogP 6.58
Molecular weight 314.462
Hydrogen Bond Acceptor 2
Hydrogen Bond Donor 1
Polar surface area 29.745
No. of rotatable bonds 7
Number of Aromatic Rings 1
Number of rings 2

ADMET Properties

Absorption level Moderate
Solubility level Very Soluble
Blood Brain Barrier Very High
Plasma protein binding Binder
CYP2D6 inhibition Non-Inhibitor

Other Biological Properties

  • Antimicrobial, antiinflammatory, analgesic, and antidepressant activity

References

    1. https://doi.org/10.1002/ptr.5271


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