| ImmunCR Id : | ICR20 |
| Chemical Name : | Stigmasterol |
| Plant Source : | Clinacanthus nutans |
| Nutraceutical information : | Edible, found in Croton sublyratus, Ficus hirta, Eclipta prostrate, Parkia speciosa, Gypsophila, Butea monosperma oldhamiana, Aralia cordata |
| Mode of administration : | Injection |
| Immunomodulatory mechanism : | Attenuation of T-cell proliferation and improvement of Th1 and Th2 imbalance; Antithyroidal-lower T3 and T4 level with reduced activity of hepatic G-6-Pase; Anti-skin cancer; Anti arthritic; Neuroprotective |
| Description : | It is an unsaturated non-polar plant sterol found in many plants associated with the synthesis of different hormones like androgen, progesterone, estrogen, corticoids. The chemical name for Stigmasterol is (3S, 8S, 9S, 10R,13R, 14S, 17R)-17-[(E, 2R, 5S)-5 ethyl-6-methylhept-3-en-2-yl]-10, 13-dimethyl-2, 3, 4, 7, 8, 9, 11, 12, 14, 15,16, 17-dodecahydro-1Hcyclopenta[a]phenanthren-3-ol |
| IUPAC Name | (3S,8S,9S,10R,13R,14S,17R)-17-[(E,2R,5S)-5-ethyl-6-methylhept-3-en-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol |
| SMILES | CC[C@H](/C=C/[C@@H](C)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@@H](C4)O)C)C)C(C)C |
| Formula | C29H48O |
| InchiKey | HCXVJBMSMIARIN-PHZDYDNGSA-N |
| Kingdom | Organic compounds |
| Superclass | Lipids and lipid-like molecules |
| Class | Steroids and steroid derivatives |
| Subclass | Stigmastanes and derivatives |
| LogP | 7.639 |
| Molecular weight | 412.691 |
| Hydrogen Bond Acceptor | 1 |
| Hydrogen Bond Donor | 1 |
| Polar surface area | 20.815 |
| No. of rotatable bonds | 5 |
| Number of Aromatic Rings | 0 |
| Number of rings | 4 |
| Absorption level | Very low |
| Solubility level | Very Soluble |
| Blood Brain Barrier | Undefined |
| Plasma protein binding | Binder |
| CYP2D6 inhibition | Non-Inhibitor |
