| ImmunCR Id : | ICR155 |
| Chemical Name : | Glycyrrhetinic acid |
| Plant Source : | Glycyrrhiza glabra |
| Nutraceutical information : | Dieatry Supplement |
| Mode of administration : | --- |
| Immunomodulatory mechanism : | The anti-inflammatory mechanism of GA is realized via cytokines like interferon-γ, tumor necrotizing factor-α, interleukin- (IL-) 1β, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12, and IL-17. They also modulate anti-inflammatory mechanisms like intercellular cell adhesion molecule 1 and P-selectin, enzymes like inducible nitric oxide synthase (iNOS), and transcription factors such as nuclear factor-kappa B, signal transducer and activator of transcription- (STAT-) 3, and STAT-6. |
| Description : | An oleanolic acid from GLYCYRRHIZA that has some antiallergic, antibacterial, and antiviral properties. It is used topically for allergic or infectious skin inflammation and orally for its aldosterone effects in electrolyte regulation. |
| IUPAC Name | 10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-3,4,5,6,6a,7,8,8a,10,11,12,14b-dodecahydro-1H-picene-2-carboxylic acid |
| SMILES | --- |
| Formula | C30H46O4 |
| InchiKey | MPDGHEJMBKOTSU-UHFFFAOYSA-N |
| Kingdom | --- |
| Superclass | --- |
| Class | --- |
| Subclass | --- |
| LogP | --- |
| Molecular weight | --- |
| Hydrogen Bond Acceptor | --- |
| Hydrogen Bond Donor | --- |
| Polar surface area | --- |
| No. of rotatable bonds | --- |
| Number of Aromatic Rings | --- |
| Number of rings | --- |
| Absorption level | --- |
| Solubility level | --- |
| Blood Brain Barrier | --- |
| Plasma protein binding | --- |
| CYP2D6 inhibition | --- |
