Immunomodulatory Function of Nutritionals and Nutraceuticals for Health and Wellness

Nutraceutical Profile


ImmunCR Id :	ICR15
Chemical Name :	Punicalagin
Plant Source :	Punica granatum
Nutraceutical information :	Edible, Highest occurance in Punica granatum, Terminalia catappa, fruits, peel (pericarp), seeds, flowers, leaves and bark, as well as in the fruits of myrobalan (Terminalia chebula), leaves of yellow wood (Terminalia oblongata)
Mode of administration :	Orally


Immunomodulatory mechanism :	Antiproliferative activity against tumor cells through inhibition of cell proliferation and induction of apoptosis via upregulation of Bax; Casp-3 and 9; cytochrome C; ROS; cytosolic STAT-3, p53; cytosolic NF-κb-p65, downregulation of Bcl-2; Jak-1; nuclear STAT-3, nuclear NF-κb-p65; Induction of apoptosis-independent cell death via autophagy through the activation of MAPK and inhibition of mtor signaling via upregulating LC3-II conversion, beclin-1; phosphorylated ERK 1/2 and p38 and downregulating p62; phosphorylated p70, S6, and 4E-BP1 ; anti-inflammatory action through inhibiting the production of tumor necrosis factor alpha (TNF)-α and interleukin (IL)-1β or IL-6 by macrophages in primary human chondrocytes; suppresses NF-kb and MAPK signaling pathways to suppress NO, TNF-α and IL-6; suppresses various signaling pathways, including NF-kβ, MAPK, Bcl-XL and LKB1-AMPK-p27
Description :	It is an ellagitannin polyphenolic compound existing as alpha and beta forms in pomegranate, Indian Almond capable of immunosuppresive actions and anti-cancer abilities through different signalling pathways.

Immunomodulatory mechanism :

Antiproliferative activity against tumor cells through inhibition of cell proliferation and induction of apoptosis via upregulation of Bax; Casp-3 and 9; cytochrome C; ROS; cytosolic STAT-3, p53; cytosolic NF-κb-p65, downregulation of Bcl-2; Jak-1; nuclear STAT-3, nuclear NF-κb-p65; Induction of apoptosis-independent cell death via autophagy through the activation of MAPK and inhibition of mtor signaling via upregulating LC3-II conversion, beclin-1; phosphorylated ERK 1/2 and p38 and downregulating p62; phosphorylated p70, S6, and 4E-BP1 ; anti-inflammatory action through inhibiting the production of tumor necrosis factor alpha (TNF)-α and interleukin (IL)-1β or IL-6 by macrophages in primary human chondrocytes; suppresses NF-kb and MAPK signaling pathways to suppress NO, TNF-α and IL-6; suppresses various signaling pathways, including NF-kβ, MAPK, Bcl-XL and LKB1-AMPK-p27

Description :

It is an ellagitannin polyphenolic compound existing as alpha and beta forms in pomegranate, Indian Almond capable of immunosuppresive actions and anti-cancer abilities through different signalling pathways.

Chemical Structure Information


IUPAC Name	(1R,35R,38R,55S)-6,7,8,11,12,23,24,27,28,29,37,43,44,45,48,49,50-heptadecahydroxy-2,14,21,33,36,39,54-heptaoxaundecacyclo[33.20.0.04,9.010,19.013,18.016,25.017,22.026,31.038,55.041,46.047,52]pentapentaconta-4,6,8,10,12,16,18,22,24,26,28,30,41,43,45,47,49,51-octadecaene-3,15,20,32,40,53-hexon
SMILES	C1C2C(C3C(C(O2)O)OC(=O)C4=CC(=C(C(=C4C5=C(C(=C(C=C5C(=O)O3)O)O)O)O)O)O)OC(=O)C6=CC(=C(C(=C6C7=C(C(=C8C9=C7C(=O)OC2=C(C(=C(C3=C(C(=C(C=C3C(=O)O1)O)O)O)C(=C92)C(=O)O8)O)O)O)O)O)O)O
Formula	C48H28O30
InchiKey	ZJVUMAFASBFUBG-UHFFFAOYSA-N

Chemical Classification


Kingdom	Organic compounds
Superclass	Phenylpropanoids and polyketides
Class	Tannins
Subclass	Hydrolyzable tannins

Physicochemical properties


LogP	3.405
Molecular weight	1084.72
Hydrogen Bond Acceptor	30
Hydrogen Bond Donor	17
Polar surface area	520.179
No. of rotatable bonds	0
Number of Aromatic Rings	6
Number of rings	11

ADMET Properties


Absorption level	Very low
Solubility level	Very Soluble
Blood Brain Barrier	Undefined
Plasma protein binding	Non-Binder
CYP2D6 inhibition	Non-Inhibitor

Other Biological Properties