ImmunoCR
A repository of plant based immunomodulatory compounds
ImmunoCR
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Nutraceutical Profile

ImmunCR Id : ICR139
Chemical Name : beta-Glucan
Plant Source : Cereal grains, particularly oats and barley
Nutraceutical information : Used as a dieatry supplement
Mode of administration : Oral
Immunomodulatory mechanism : β-Glucans initiate immune responses via immune cells, which become activated by the binding of the polymer to specific receptors
Description : Beta-Glucan is a polysaccharide isolated from the cell walls of bacteria, plants, and fungi with immunostimulant and antineoplastic activities. In a solubilized form, beta-glucan binds to a lectin site within complement receptor 3 (CR3) on leukocytes, priming the receptor to trigger cytotoxic degranulation of leukocytes when leukocyte CR3 binds to complement 3 (iC3b)-coated tumors. Thus, the attachment of beta-glucan to CR3 of circulating leukocytes simulates leukocytes to kill iC3b-coated tumor cells in the same way as they kill iC3b-coated yeast. (NCI04)

Chemical Structure Information

IUPAC Name (2S,3R,4S,5S,6R)-2-[(2R,4R,5R,6S)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2R,4R,5R,6S)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol
SMILES C([C@@H]1[C@H]([C@@H]([C@H]([C@@H](O1)OC2[C@H](O[C@H]([C@@H]([C@H]2O)O)OC3[C@H](O[C@@H]([C@@H]([C@H]3O)O)O)CO)CO)O)O)O)O
Formula C18H32O16
InchiKey FYGDTMLNYKFZSV-URKRLVJHSA-N

Chemical Classification

Kingdom Organic compounds
Superclass Organic oxygen compounds
Class Organooxygen compounds
Subclass Carbohydrates and carbohydrate conjugates

Physicochemical properties

LogP -6.008
Molecular weight 504.437
Hydrogen Bond Acceptor 16
Hydrogen Bond Donor 11
Polar surface area 273.621
No. of rotatable bonds 7
Number of Aromatic Rings 0
Number of rings 3

ADMET Properties

Absorption level Very low
Solubility level Very Soluble
Blood Brain Barrier Undefined
Plasma protein binding Non-Binder
CYP2D6 inhibition Non-Inhibitor

Other Biological Properties

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References

    1.  https://doi.org/10.3389/fimmu.2020.00658
    2. https://doi.org/10.1016/j.dci.2016.03.003


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