| ImmunCR Id : | ICR132 |
| Chemical Name : | alpha-Mangostin |
| Plant Source : | Mangosteen |
| Nutraceutical information : | --- |
| Mode of administration : | Liquid |
| Immunomodulatory mechanism : | α-mangostin was able to inhibit IL-2 release without interfering with human immune cells |
| Description : | Alpha-mangostin is a member of the class of xanthones that is 9H-xanthene substituted by hydroxy group at positions 1, 3 and 6, a methoxy group at position 7, an oxo group at position 9 and prenyl groups at positions 2 and 8. Isolated from the stems of Cratoxylum cochinchinense, it exhibits antioxidant, antimicrobial and antitumour activities. It has a role as an antineoplastic agent, an antimicrobial agent, an antioxidant and a plant metabolite. It is a member of xanthones, a member of phenols and an aromatic ether. |
| IUPAC Name | 1,3,6-trihydroxy-7-methoxy-2,8-bis(3-methylbut-2-enyl)xanthen-9-one |
| SMILES | CC(=CCC1=C(C2=C(C=C1O)OC3=C(C2=O)C(=C(C(=C3)O)OC)CC=C(C)C)O)C |
| Formula | C24H26O6 |
| InchiKey | GNRIZKKCNOBBMO-UHFFFAOYSA-N |
| Kingdom | Organic compounds |
| Superclass | Organoheterocyclic compounds |
| Class | Benzopyrans |
| Subclass | 1-benzopyrans |
| LogP | 5.935 |
| Molecular weight | 410.46 |
| Hydrogen Bond Acceptor | 6 |
| Hydrogen Bond Donor | 3 |
| Polar surface area | 97.607 |
| No. of rotatable bonds | 5 |
| Number of Aromatic Rings | 2 |
| Number of rings | 3 |
| Absorption level | low |
| Solubility level | Very Soluble |
| Blood Brain Barrier | Undefined |
| Plasma protein binding | Binder |
| CYP2D6 inhibition | Non-Inhibitor |
