ImmunoCR
A repository of plant based immunomodulatory compounds

List of Probiotics

Species Peptides/Molecules Activity/Effects References
Bifidobacterium sp. Pili Upregulate TNFα, Downlregulate IL10 https://doi.org/10.3390/nu12020391
Several species Flagellin Upregulate IL12 https://doi.org/10.3390/nu12020391
Lactobacillus sp. p75 and p40 DownregulateCell apoptosis https://doi.org/10.3390/nu12020391
Lactobacillus rhamnosus HM0539 Downregulate LPS- or TNFα-mediated barrier injury https://doi.org/10.3390/nu12020391
Akkermansia muciniphila Pili-structures Amelioration of metabolic syndrome and type-2 diabetes https://doi.org/10.3390/nu12020391
Faecalibacterium prautsnitzii MAM Downregulate NF-kB pathways, Downregulate Th1 and Th2 responses https://doi.org/10.3390/nu12020391
Ruminococcus gnavus IbpA and IpB Targets for IgA coating https://doi.org/10.3390/nu12020391
Lactobacillus plantarum GSTp Upregulate IL10, Downregulate IL12 https://doi.org/10.3390/nu12020391
Bifidobacterium longum FR-16 Upregulate Th17, Th22 responses https://doi.org/10.3390/nu12020391
Bacteroides fragilis LR-17 Upregulate Th17, Th22 responses https://doi.org/10.3390/nu12020391
Several species Short-chain fatty acids Activation of GPCRs, Downregulation of histone deacetylase https://doi.org/10.3390/nu12020391
Several species Short-chain fatty acids NF-κB inhibition, Upregulate IgA secretion, Downregulate pro-inflammatory cytokines, Upregulate leukocyte recruitment https://doi.org/10.3390/nu12020391
Several species Propionate, butyrate Anti-inflammatory, Upregulate Treg response https://doi.org/10.3390/nu12020391
Several species Butyrate Downegulate histone deacetylase, Upregulate Treg https://doi.org/10.3390/nu12020391
Several species Propionate Affects Th2 response https://doi.org/10.3390/nu12020391
Several species Branched-chain fatty acids Inhibition of histone deacetylase https://doi.org/10.3390/nu12020391
Several species Indole-3-aldehyde, indole-3-propionate and indole-3-acetic acid Upregulate Barrier integrity and immune cell function https://doi.org/10.3390/nu12020391
Peptostreptococcus sp. 3-indoleacrylic acid Upregulate Epithelial barrier and immune cell function https://doi.org/10.3390/nu12020391
Several species D-tryptophan Downregulate Th2 response https://doi.org/10.3390/nu12020391
Several species Kynurenic acid, niacin, nicotinic acid Gut homeostasis regulators, anti-inflammatory https://doi.org/10.3390/nu12020391
Several species Glutamine, histidine and glycine- derived metabolites Influence gut homeostasis and immune cell function https://doi.org/10.3390/nu12020391
Marine fungus Phoma herbarum YS4108 α-d-glucan Immunomodulatory functions by regulating T lymphocytes and dendritic cells in vitro. https://doi.org/10.3390/md20070422